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Pharmacological action:
Sulfamethoxazole upsets the synthesis of dihydrofolic acid in bacterial cells, suppressing the inclusion of para-aminobenzoic acid into a molecule. Trimethoprim reinforces sulfamethoxazole’s effect, breaking the reconstruction of dihydrofolic acid into tetrahydrofolic acid - the active form of folic acid, which is responsible for protein metabolism and microbial cell division.
Indications:
• infections of urogenital system: urethritis, cystitis, pyelitis, pyelonephritis, prostatitis, epididymitis, gonorrhea (men and women), chancroid, lymphogranuloma venereum, venereal granuloma;
• respiratory infections: bronchitis (acute and chronic), multiple bronchiectasis, croupous pneumonia, bronchopneumonia, pneumocystic pneumonia;
• ENT-organs infections: otitis media, sinusitis, laryngitis, tonsillitis, scarlet fever;
• infections of gastrointestinal tract: typhoid, paratyphoid, cholera, dysentery, cholecystitis, cholangitis, gastroenteritis caused by Escherichia coli;
• skin and soft tissue infections: acne, furunculosis, pyoderma;
• wound infections: osteomyelitis (acute and chronic), etc;
• osteoarticular diseases, brucellosis (acute), Lutz-Splendore-Almeida disease, malaria (Plasmodium falciparum), toxoplasmosis.
Sulfamethoxazole upsets the synthesis of dihydrofolic acid in bacterial cells, suppressing the inclusion of para-aminobenzoic acid into a molecule. Trimethoprim reinforces sulfamethoxazole’s effect, breaking the reconstruction of dihydrofolic acid into tetrahydrofolic acid - the active form of folic acid, which is responsible for protein metabolism and microbial cell division.
Indications:
• infections of urogenital system: urethritis, cystitis, pyelitis, pyelonephritis, prostatitis, epididymitis, gonorrhea (men and women), chancroid, lymphogranuloma venereum, venereal granuloma;
• respiratory infections: bronchitis (acute and chronic), multiple bronchiectasis, croupous pneumonia, bronchopneumonia, pneumocystic pneumonia;
• ENT-organs infections: otitis media, sinusitis, laryngitis, tonsillitis, scarlet fever;
• infections of gastrointestinal tract: typhoid, paratyphoid, cholera, dysentery, cholecystitis, cholangitis, gastroenteritis caused by Escherichia coli;
• skin and soft tissue infections: acne, furunculosis, pyoderma;
• wound infections: osteomyelitis (acute and chronic), etc;
• osteoarticular diseases, brucellosis (acute), Lutz-Splendore-Almeida disease, malaria (Plasmodium falciparum), toxoplasmosis.
Other names of this medication: Bactrim, Apo-Sulfatrim, Apo-Sulfatrim DS, Bactrim DS, Bactrim I.V., Bactrim Pediatric, Co-trimoxazole, Cofatrim Forte, Coptin, Coptin 1, Cotrim, Cotrim DS, Cotrim Pediatric, Cotrimazine, Cotrimoxazole, Novo-Trimel, Novo-Trimel D.S., Nu-Cotrimox, Nu-Cotrimox DS, Roubac, SMZ-TMP, Septra, Septra DS, Septra Grape Suspension, Septra I.V., Septra Suspension, Sulfatrim, Sulfatrim Pediatric, Sulfatrim S/S, Sulfatrim Suspension, Sulfatrim-DS, Sulfamethoxazole, Trimethoprim, Bactrim.
